Article
Increased burden of cardiovascular disease in carriers of APOL1 genetic variants.
Circulation research - 28 Feb 2014
Ito Kaoru, Bick Alexander G, Flannick Jason, Friedman David J, Genovese Giulio, Parfenov Michael G, Depalma Steven R, Gupta Namrata, Gabriel Stacey B, Taylor Herman A, Fox Ervin R, Newton-Cheh Christopher, Kathiresan Sekar, Hirschhorn Joel N, Altshuler David M, Pollak Martin R, Wilson James G, Seidman J G, Seidman Christine
Abstract excerpt
RATIONALE: Two distinct alleles in the gene encoding apolipoprotein L1 (APOL1), a major component of high-density lipoprotein, confer protection against Trypanosoma brucei rhodesiense infection and also increase risk for chronic kidney disease. Approximately 14% of Americans with African ancestry carry 2 APOL1 risk alleles, accounting for the high chronic kidney disease burden in this population. OBJECTIVE: We...
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