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Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity

8 Oct 2022

Abstract excerpt

Impairment in the hypothalamic-pituitary-adrenal (HPA) axis and cortisol pathway may be major contributing factors to the common pathogenesis of major depressive disorders (MDD) and type 2 diabetes (T2D). A significant player in the neuroendocrine HPA axis and cortisol response is the glucocorticoid receptor (GR), which is encoded by the nuclear receptor subfamily 3 group C member (NR3C1) gene. Variants in the...

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PMID: 36233250
DOI: 10.3390/ijms231911951

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