Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PLA2G2A Phospholipase Promotes Fatty Acid Synthesis and Energy Metabolism in Pancreatic Cancer Cells with K-ras Mutation.

International journal of molecular sciences - 3 Oct 2022

Zhang Mingquan, Xiang Rong, Glorieux Christophe, Huang Peng

Abstract excerpt

Oncogenic K-ras is often activated in pancreatic ductal adenocarcinoma (PDAC) due to frequent mutation (>90%), which drives multiple cellular processes, including alterations in lipid metabolism associated with a malignant phenotype. However, the role and mechanism of the altered lipid metabolism in K-ras-driven cancer remains poorly understood. In this study, using human pancreatic epithelial cells harboring...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Line, Tumor

Share to Energy Metabolism

Share to Fatty Acids

Share to Lipids

Share to Pancreatic Neoplasms

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 36233022
DOI: 10.3390/ijms231911721
PMCID: PMC9570406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PLA2G2A Phospholipase Promotes Fatty Acid Synthesis and Energy Metabolism in Pancreatic Cancer Cells with K-ras Mutation.PMID 36233022Read ↗

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma.Semantic proximity Read ↗

Eicosapentaenoic Acid Inhibits KRAS Mutant Pancreatic Cancer Cell Growth by Suppressing Hepassocin Expression and STAT3 Phosphorylation.Semantic proximity Read ↗

Novel strategy for oncogenic alteration-induced lipid metabolism reprogramming in pancreatic cancer.Semantic proximity Read ↗

SREBP1 is associated with lipid-metabolic reprogramming and apoptotic regulation in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

Molecular Pathways: Fatty Acid SynthaseSemantic proximity Read ↗

Metabolism addiction in pancreatic cancer.Semantic proximity Read ↗

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer.Semantic proximity Read ↗

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancerSemantic proximity Read ↗

SQLE-mediated squalene metabolism is critical for mitochondrial biogenesis and tumor development in K-ras-driven cancerSemantic proximity Read ↗

Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterationsSemantic proximity Read ↗

Bilayer Forming Phospholipids as Targets for Cancer TherapySemantic proximity Read ↗

NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.