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Article

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer.

Cancer research - 15 Apr 2026

Burge Rachel A, Bialousow Lucas, Linke Amanda J, Coalson Hannah S, Adair Sara J, Sundararaj Kamala, Smith Merissa, Bumbleburg Cameron, Bauer Todd W, Kashatus David F, Hobbs G Aaron

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is defined by the near universal occurrence of KRAS mutations. The KRASG12R mutation is detected in approximately 15% to 20% of patients with PDAC and rare in other KRAS-mutant cancers. KRASG12R is unable to activate the lipid kinase PIK3CA, suggesting that alternative mechanisms might be employed to activate KRASG12R-independent PI3K signaling in PDAC. In this study, we...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pancreatic Neoplasms

Share to Phosphatidylinositol 3-Kinases

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 41134579
DOI: 10.1158/0008-5472.CAN-24-4501
PMCID: PMC12614194

Genes

KRAS
PTEN
PIK3CA
PIK3CG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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