Article

SQLE-mediated squalene metabolism is critical for mitochondrial biogenesis and tumor development in K-ras-driven cancer

2024-02-21

Abstract excerpt

<title>Abstract</title> <p>Despite the widely recognition of K-ras oncogenic role, the underlying biochemical pathways and metabolic regulation that promote cancer development remain to be characterized. Here we show that SQLE, a key enzyme in cholesterol synthesis, is upregulated by K-ras and its expression levels are closely correlated with poor prognosis of pancreatic cancer patients. Mechanistically, SQLE is...

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Literature Corpus work: b31c6c0f-6eeb-534a-8fca-3b7fcb4d27ac
DOI: 10.21203/rs.3.rs-3819326/v1

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