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Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

11 Dec 2015

Abstract excerpt

Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. AML is a heterogeneous malignancy characterized by distinct genetic abnormalities. Recent discoveries have highlighted an additional important role of dysregulated epigenetic mechanisms in the pathogenesis of the disease. In contrast to genetic changes, epigenetic modifications are frequently reversible, which provides opportunities...

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PMID: 26660432
DOI: 10.1182/blood-2015-07-604512

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