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Epigenetic regulators and their impact on therapy in acute myeloid leukemia

29 Feb 2016

Abstract excerpt

Genomic studies of hematologic malignancies have identified a spectrum of recurrent somatic alterations that contribute to acute myeloid leukemia initiation and maintenance, and which confer sensitivities to molecularly targeted therapies. The majority of these genetic events are small, site-specific alterations in DNA sequence. In more than two thirds of patients with de novo acute myeloid leukemia mutations...

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PMID: 26928248
DOI: 10.3324/haematol.2015.140822

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