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Article

Genetic Analysis Implicates Dysregulation of SHANK2 in Renal Cell Carcinoma Progression.

International journal of environmental research and public health - 30 Sept 2022

Chang Chi-Fen, Huang Shu-Pin, Hsueh Yu-Mei, Geng Jiun-Hung, Huang Chao-Yuan, Bao Bo-Ying

Abstract excerpt

SH3 and multiple ankyrin repeat domains (SHANK) is a family of scaffold proteins that were first identified to be involved in balancing synaptic transmission via regulation of intracellular signalling crosstalk and have been linked to various cancers. However, the role of the SHANK genes in renal cell carcinoma (RCC) remains to be elucidated. In this study, we aimed to evaluate whether genetic variants in SHANK...

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Identifiers

PMID: 36231770
DOI: 10.3390/ijerph191912471
PMCID: PMC9566262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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