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Article

Germline genetic variants in somatically significantly mutated genes in tumors are associated with renal cell carcinoma risk and outcome.

Carcinogenesis - 28 May 2018

Shu Xiang, Gu Jianchun, Huang Maosheng, Tannir Nizar M, Matin Surena F, Karam Jose A, Wood Christopher G, Wu Xifeng, Ye Yuanqing

Abstract excerpt

Genome-wide association studies (GWAS) have identified 13 susceptibility loci for renal cell carcinoma (RCC). Additional genetic loci of risk remain to be explored. Moreover, the role of germline genetic variants in predicting RCC recurrence and overall survival (OS) is less understood. In this study, we focused on 127 significantly mutated genes from The Cancer Genome Atlas (TCGA) Pan-Cancer Analysis across 12...

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Carcinoma, Renal Cell
Case-Control Studies
Genome-Wide Association Study
Kidney Neoplasms
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Quantitative Trait Loci

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Open in PubMed Open full text

Identifiers

PMID: 29635281
DOI: 10.1093/carcin/bgy021
PMCID: PMC5972595

Genes

ERBB4
ATM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Germline genetic variants in somatically significantly mutated genes in tumors are associated with renal cell carcinoma risk and outcome.PMID 29635281Read ↗

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