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Germline genetic variants in somatically significantly mutated genes in tumors are associated with renal cell carcinoma risk and outcome.

Carcinogenesis - 28 May 2018

Shu Xiang, Gu Jianchun, Huang Maosheng, Tannir Nizar M, Matin Surena F, Karam Jose A, Wood Christopher G, Wu Xifeng, Ye Yuanqing

Abstract excerpt

Genome-wide association studies (GWAS) have identified 13 susceptibility loci for renal cell carcinoma (RCC). Additional genetic loci of risk remain to be explored. Moreover, the role of germline genetic variants in predicting RCC recurrence and overall survival (OS) is less understood. In this study, we focused on 127 significantly mutated genes from The Cancer Genome Atlas (TCGA) Pan-Cancer Analysis across 12...

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Identifiers

PMID: 29635281
DOI: 10.1093/carcin/bgy021
PMCID: PMC5972595

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Germline genetic variants in somatically significantly mutated genes in tumors are associated with renal cell carcinoma risk and outcome.PMID 29635281Read ↗

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