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Article

Genetic alteration in notch pathway is associated with better prognosis in renal cell carcinoma.

BioFactors (Oxford, England) - 1 Jan 2000

Feng Chenchen, Xiong Zuquan, Jiang Haowen, Ding Qiang, Fang Zujun, Hui Wen

Abstract excerpt

Notch signaling was associated with a variety of cancers but was not comprehensively studied in clear-cell renal cell carcinoma (ccRCC). We have in this study studied the genetic alteration (mutation and copy number variance) of Notch gene set in the Cancer Genome Atlas (TCGA) Kidney Renal Clear Cell Carcinoma (KIRC) database. We found that Notch pathway was frequently altered in ccRCC. The Notch gene set was...

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Share to Carcinoma, Renal Cell
Share to Disease-Free Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA Copy Number Variations

Share to Gene Expression Regulation, Neoplastic

Share to p300-CBP Transcription Factors

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Share to Receptors, Notch

Source

Identifiers

PMID: 26662507
DOI: 10.1002/biof.1250

Genes

MAML1
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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