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Article

Comparative STAT3-Regulated Gene Expression Profile in Renal Cell Carcinoma Subtypes

26 Feb 2019

Abstract excerpt

Renal cell carcinomas (RCC) are heterogeneous and can be further classified into three major subtypes including clear cell, papillary and chromophobe. Signal transducer and activator of transcription 3 (STAT3) is commonly hyperactive in many cancers and is associated with cancer cell proliferation, invasion, migration, and angiogenesis. In renal cell carcinoma, increased STAT3 activation is associated with...

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PMID: 30863721
DOI: 10.3389/fonc.2019.00072

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