SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling.

doi:10.1038/s41419-021-03958-4

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SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling.

Cell death & disease - 3 Jul 2021

Wang Jiangyi, Zou Yun, Du Bowen, Li Wenzhi, Yu Guopeng, Li Long, Zhou Lin, Gu Xin, Song Shangqing, Liu Yushan, Zhou Wenquan, Xu Bin, Wang Zhong

Abstract excerpt

Over the last decade, more than 10 independent SNPs have been discovered to be associated with the risk of renal cell carcinoma among different populations. However, the biological functions of them remain poorly understood. In this study, we performed eQTL analysis, ChIP-PCR, luciferase reporter assay, and Cox regression analysis to identify the functional role and underlying mechanism of rs67311347 in RCC. The...

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PMID: 34218253
DOI: 10.1038/s41419-021-03958-4
PMCID: PMC8254807

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