Article
Ultra-sensitive molecular detection of gene fusions from RNA using ASPYRE.
BMC medical genomics - 12 Oct 2022
Gray Eleanor R, Mordaka Justyna M, Christoforou Efthimia R, von Bargen Kristine, Potts Nicola D, Xyrafaki Christina, Silva Ana-Luisa, Stolarek-Januszkiewicz Magdalena, Anton Katarzyna, Powalowska Paulina K, Andreazza Simonetta, Tomassini Alessandro, Palmer Rebecca N, Cooke Aishling, Osborne Robert J, Balmforth Barnaby W
Abstract excerpt
BACKGROUND: RNA is a critical analyte for unambiguous detection of actionable mutations used to guide treatment decisions in oncology. Currently available methods for gene fusion detection include molecular or antibody-based assays, which suffer from either being limited to single-gene targeting, lack of sensitivity, or long turnaround time. The sensitivity and predictive value of next generation sequencing...
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