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Article

Key considerations for comprehensive validation of an RNA fusion NGS panel

8 Jun 2020

Abstract excerpt

OBJECTIVES: Validation of RNA-based NGS assays for the detection of therapeutically targetable gene fusions is challenging. Here, we report systematic validation and quality control monitoring of our targeted fusion panel for the detection of 17 clinically relevant fusion transcripts across several tumor types. We implemented this RNA Fusion Panel as a reflex test for tumors lacking DNA driver mutations. DESIGN:...

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PMID: 32613069
DOI: 10.1016/j.plabm.2020.e00173

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