Anchored random reverse primer sequencing for quantitative detection of novel gene fusions.

Abstract excerpt

Identifying novel gene fusions is critical for cancer diagnosis and drug development. While a few advanced methods have shown the capability to detect gene fusions involving unknown partners, comprehensive detection of gene fusions, especially of those with low copy numbers, remains a challenge. Indeed, most current panel-based sequencing methods fall short in reliability and cost efficiency. Here we present a...

Topics

• Humans
• Gene Fusion
• DNA Primers
• Female
• Prostatic Neoplasms
• Uterine Cervical Neoplasms