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Article

Single-copy detection of somatic variants from solid and liquid biopsy.

Scientific reports - 16 Mar 2021

Silva Ana-Luisa, Powalowska Paulina Klaudyna, Stolarek Magdalena, Gray Eleanor Ruth, Palmer Rebecca Natalie, Herman Bram, Frayling Cameron Alexander, Balmforth Barnaby William

Abstract excerpt

Accurate detection of somatic variants, against a background of wild-type molecules, is essential for clinical decision making in oncology. Existing approaches, such as allele-specific real-time PCR, are typically limited to a single target gene and lack sensitivity. Alternatively, next-generation sequencing methods suffer from slow turnaround time, high costs, and are complex to implement, typically limiting...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33727644
DOI: 10.1038/s41598-021-85545-3
PMCID: PMC7966381

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