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Article

Extensive cross-reactive T cell epitopes across SARS-CoV-2 Omicron variant spikes with finite immune evasion mutations.

Journal of translational medicine - 30 Sept 2025

Gan Mengze, Cao Jinge, Ouyang Qi, Xu Xinyue, Wang Xingxing, Dan Peihang, Yao Yinlong, Fu Hui, Yao Xuanyu, Lin Xiaosong, Lei Qing, Fan Xionglin

Abstract excerpt

BACKGROUND: The impact of spike protein mutations on T cell responses, particularly in SARS-CoV-2 Omicron variants, remains incompletely elucidated. METHODS: In this study, DNA vaccines encoding the spike protein of both the ancestral virus and Omicron variants were developed and administered in conjunction with a Th1-type adjuvant to BALB/c mice. Cross-reactive T cell responses to the spike proteins were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41029649
DOI: 10.1186/s12967-025-07076-z
PMCID: PMC12487199

Genes

CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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