Article

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination

2021-06-01

Abstract excerpt

Emerging SARS-CoV-2 variants pose a threat to human immunity induced by natural infection and vaccination. We assessed the recognition of three variants of concern (B.1.1.7, B.1.351 and P.1) in cohorts of COVID-19 patients ranging in disease severity (n = 69) and recipients of the Pfizer/BioNTech vaccine (n = 50). Spike binding and neutralization against all three VOC was substantially reduced in the majority of s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e247c2fd-bc43-5ffe-a499-795715f02d1c
DOI: 10.1101/2021.05.26.21257441

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccinationDOI 10.1101/2021.05.26.21257441Read

Immune Evasion of SARS-CoV-2 Emerging Variants: What Have We Learnt So Far?Semantic proximity Read

SARS-CoV-2 variant B.1.1.7 is susceptible to neutralizing antibodies elicited by ancestral spike vaccines.Semantic proximity Read

SARS-CoV-2 Variant Exposures Elicit Antibody Responses With Differential Cross-Neutralization of Established and Emerging Strains Including Delta and OmicronSemantic proximity Read

Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.Semantic proximity Read

SARS-CoV-2 Variant B.1.1.7 is Susceptible to Neutralizing Antibodies Elicited by Ancestral Spike VaccinesSemantic proximity Read

Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients.Semantic proximity Read

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.Semantic proximity Read

SARS-CoV-2 neutralizing antibodies: Longevity, breadth, and evasion by emerging viral variantsSemantic proximity Read

Clinical course impacts early kinetics and long-term magnitude and amplitude of SARS-CoV-2 neutralizing antibodies beyond one year after infectionSemantic proximity Read

Increased seroprevalence and improved antibody responses following third primary SARS-CoV-2 immunisation: an update from the COV-AD studySemantic proximity Read

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429Semantic proximity Read

Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platformSemantic proximity Read