Article

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output

2024-03-27

Abstract excerpt

Cell size and biosynthetic capacity generally increase with increased DNA content. Polyploidy has therefore been proposed to be an adaptive strategy to increase cell size in specialized tissues with high biosynthetic demands. However, if and how DNA concentration limits cellular biosynthesis in vivo is not well understood, and the impacts of polyploidy in non-disease states is not well studied. Here, we show that...

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Literature Corpus work: 0065b196-e8ec-5645-97c4-0cbf85abfa5a
DOI: 10.1101/2024.03.25.586714

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