Polymorphisms in interferon pathway genes and risk of Mycobacterium tuberculosis infection in contacts of tuberculosis cases in Brazil.

doi:10.1016/j.ijid.2019.12.013

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Article

Polymorphisms in interferon pathway genes and risk of Mycobacterium tuberculosis infection in contacts of tuberculosis cases in Brazil.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Mar 2020

Cubillos-Angulo Juan Manuel, Arriaga María B, Melo Mayla G M, Silva Elisangela C, Alvarado-Arnez Lucia Elena, de Almeida Alexandre S, Moraes Milton O, Moreira Adriana S R, Lapa E Silva Jose R, Fukutani Kiyoshi F, Sterling Timothy R, Hawn Thomas R, Kritski Afrânio L, Oliveira Martha M, Andrade Bruno B

Abstract excerpt

BACKGROUND: Host genetic polymorphisms may be important in determining susceptibility to Mycobacterium tuberculosis (Mtb) infection, but their role is not fully understood. Detection of microbial DNA and activation of type I interferon (IFN) pathways regulate macrophage responses to Mtb infection. METHODS: We examined whether seven candidate gene SNPs were associated with tuberculin skin test (TST) positivity in...

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PMID: 31843671
DOI: 10.1016/j.ijid.2019.12.013
PMCID: PMC7197195

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