Single-Nucleotide Variants in the AIM2 - Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis.

doi:10.3389/fimmu.2021.604975

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Article

Single-Nucleotide Variants in the AIM2 - Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis.

Frontiers in immunology - 1 Jan 2021

Figueira Mariana Brasil de Andrade, de Lima Dhêmerson Souza, Boechat Antonio Luiz, Filho Milton Gomes do Nascimento, Antunes Irineide Assumpção, Matsuda Joycenéa da Silva, Ribeiro Thaís Rodrigues de Albuquerque, Felix Luana Sousa, Gonçalves Ariane Senna Fonseca, da Costa Allyson Guimarães, Ramasawmy Rajendranath, Pontillo Alessandra, Ogusku Mauricio Morishi, Sadahiro Aya

Abstract excerpt

Tuberculosis (TB) remains a serious public health burden worldwide. TB is an infectious disease caused by the Mycobacterium tuberculosis Complex. Innate immune response is critical for controlling mycobacterial infection. NOD-like receptor pyrin domain containing 3/ absent in melanoma 2 (NLRP3/AIM2) inflammasomes are suggested to play an important role in TB. NLRP3/AIM2 mediate the release of pro-inflammatory...

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PMID: 33868225
DOI: 10.3389/fimmu.2021.604975
PMCID: PMC8047195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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