Article
Feasibility of a novel non-invasive swab technique for serial whole-exome sequencing of cervical tumors during chemoradiation therapy.
PloS one - 1 Jan 2022
Bronk Julianna K, Kapadia Chiraag, Wu Xiaogang, Chapman Bhavana V, Wang Rui, Karpinets Tatiana V, Song Xingzhi, Futreal Andrew M, Zhang Jianhua, Klopp Ann H, Colbert Lauren E
Abstract excerpt
BACKGROUND: Clinically relevant genetic predictors of radiation response for cervical cancer are understudied due to the morbidity of repeat invasive biopsies required to obtain genetic material. Thus, we aimed to demonstrate the feasibility of a novel noninvasive cervical swab technique to (1) collect tumor DNA with adequate throughput to (2) perform whole-exome sequencing (WES) at serial time points over the...
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