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Article

Comprehensive circulating tumor DNA mutation profiling via CAPP-Seq liquid biopsy for cervical cancer.

International journal of clinical oncology - 1 May 2026

Iwahashi Naoyuki, Noguchi Tomoko, Sakai Kazuko, Yahata Tamaki, Nishioka Kaho, Fujino Megumi, Takeda Shinichiro, Suzuki Nobuhiko, Nishio Kazuto, Ino Kazuhiko

Abstract excerpt

BACKGROUND: Liquid biopsy using circulating tumor DNA (ctDNA) is a minimally invasive approach for detecting tumor-associated genomic alterations. Although ctDNA analysis has been widely explored in solid tumors, its application to cervical cancer remains limited. Cancer personalized profiling by deep sequencing (CAPP-Seq) enables sensitive ctDNA profiling via molecular barcoding and digital error suppression....

Topics

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Biomarkers, Tumor
Carcinoma, Squamous Cell
Circulating Tumor DNA
Class I Phosphatidylinositol 3-Kinases
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

High-Throughput Nucleotide Sequencing

Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 41806198
DOI: 10.1007/s10147-026-03006-1
PMCID: PMC13102940

Genes

EGFR
ERBB2
MET
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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