Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort

7 Jan 2019

Abstract excerpt

Abstract Purpose: We developed a method to monitor copy number variations (CNV) in plasma cell-free DNA (cfDNA) from patients with metastatic squamous non–small cell lung cancer (NSCLC). We aimed to explore the association between tumor-derived cfDNA and clinical outcomes, and sought CNVs that may suggest potential resistance mechanisms. Experimental Design: Sensitivity and specificity of low-pass whole-genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Genomic variations and chromosomal abnormalities
Share to Lung Cancer Treatments and Mutations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30617129
DOI: 10.1158/1078-0432.ccr-18-1593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low-pass Whole-genome Sequencing of Circulating Cell-free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical CohortPMID 30617129Read ↗

Genomic alterations of plasma cell-free DNAs in small cell lung cancer and their clinical relevance.Semantic proximity Read ↗

Genomic alterations and transcriptional phenotypes in circulating free DNA and matched metastatic tumor.Semantic proximity Read ↗

Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse.Semantic proximity Read ↗

Genomic Analysis of Circulating Tumor Cells at the Single-Cell LevelSemantic proximity Read ↗

Genomic alterations and transcriptional phenotypes in circulating tumor DNA and matched metastatic tumorSemantic proximity Read ↗

Low-coverage whole-genome sequencing of plasma cell-free DNA to predict treatment response and progression-free survival in advanced NSCLC receiving EGFR-tyrosine kinase inhibitors or chemotherapy: A pilot prospective studySemantic proximity Read ↗

CNV Detection from Circulating Tumor DNA in Late Stage Non-Small Cell Lung Cancer PatientsSemantic proximity Read ↗

Profiling of Circulating Free DNA Using Targeted and Genome-wide Sequencing in Patients with SCLCSemantic proximity Read ↗

Genomic variations in plasma cell free DNA differentiate early stage lung cancers from normal controls.Semantic proximity Read ↗

Plasma-based longitudinal mutation monitoring as a potential predictor of disease progression in subjects with adenocarcinoma in advanced non-small cell lung cancer.Semantic proximity Read ↗

LiquidCNA: Tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterationsSemantic proximity Read ↗

Longitudinal cell-free DNA characterization by low-coverage whole-genome sequencing in patients undergoing high-dose radiotherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.