Article
Serial Genotyping of the Human Papillomavirus in Cervical Cancer: An Insight Into Virome Dynamics During Chemoradiation Therapy.
International journal of radiation oncology, biology, physics - 1 Aug 2023
Sammouri Julie, Wong Matthew C, Lynn Erica J, El Alam Molly B, Lo David K, Lin Daniel, Harris Timothy H, Karpinets Tatiana V, Court Kyoko, Napravnik Tatiana Cisneros, Wu Xiaogang, Zhang Jianhua, Klopp Ann H, Ajami Nadim J, Colbert Lauren E
Abstract excerpt
PURPOSE: Human papillomavirus (HPV) is the primary driver of cervical cancer. Although studies in other malignancies correlated peripheral blood DNA clearance with favorable outcomes, research on the prognostic value of HPV clearance in gynecologic cancers using intratumoral HPV is scarce. We aimed to quantify the intratumoral HPV virome in patients undergoing chemoradiation therapy (CRT) and associate this with...
Topics
- Humans
- Female
- Uterine Cervical Neoplasms
- Human Papillomavirus Viruses
- Papillomavirus Infections
- Prospective Studies
- Genotype
- Virome
- Papillomaviridae