Somatic mutations and CRISPR/Cas9 library screening integrated analysis identifies cervical cancer drug‐resistant pathways

Abstract excerpt

To the Editor: Cervical cancer ranks the fourth cause of cancer mortality in women worldwide.1 Neoadjuvant chemotherapy has remarkable effects on advanced cervical cancer,2 but 15%–34% of patients do not respond to drug treatment.3 Using the integrated analysis of whole-exome sequencing (WES) and CRISPR screening, our data explored the intrinsic mechanisms that contribute to chemoresistance. We performed WES...

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