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Article

Myeloid cell-specific ablation of Runx2 gene exacerbates post-infarct cardiac remodeling

5 Oct 2022

Abstract excerpt

Abstract Runt-related transcription factor 2 (Runx2), a regulator of osteoblast differentiation, is pathologically involved in vascular calcification; however, the significance of Runx2 in cardiac homeostasis remains unclear. Here, we investigated the roles of Runx2 in cardiac remodeling after myocardial infarction (MI). The expression of Runx2 mRNA and protein was upregulated in murine hearts after MI. Runx2 was...

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PMID: 36198906
DOI: 10.1038/s41598-022-21202-7

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