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Article

Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration.

Development (Cambridge, England) - 27 Apr 2020

Koth Jana, Wang Xiaonan, Killen Abigail C, Stockdale William T, Potts Helen G, Jefferson Andrew, Bonkhofer Florian, Riley Paul R, Patient Roger K, Göttgens Berthold, Mommersteeg Mathilda T M

Abstract excerpt

Runx1 is a transcription factor that plays a key role in determining the proliferative and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence of runx1 results in increased myocardial survival and proliferation, and overall heart regeneration, accompanied by...

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Identifiers

PMID: 32341028
DOI: 10.1242/dev.186569
PMCID: PMC7197712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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