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Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction

2026-06-09

Abstract excerpt

<h4>Background</h4> Heart failure with preserved ejection fraction (HFpEF) is a systemic inflammatory syndrome with few effective therapies. Soluble urokinase plasminogen activator receptor (suPAR), a circulating immune-derived glycoprotein, independently predicts adverse outcomes in HFpEF beyond natriuretic peptides, but whether it is a causal driver or a passive marker of inflammatory burden has remained unreso...

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Literature Corpus work
a45dddf5-868f-5278-9c2c-0163da456a33
DOI
10.64898/2026.06.04.730230
Open publication

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Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection FractionDOI 10.64898/2026.06.04.730230
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