Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

doi:10.1182/blood.2020005734

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Article

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1.

Blood - 4 Feb 2021

Kohlhaas Vivien, Blakemore Stuart James, Al-Maarri Mona, Nickel Nadine, Pal Martin, Roth Andreas, Hövelmeyer Nadine, Schäfer Stephan C, Knittel Gero, Lohneis Philipp, Nikolic Milos, Wiederstein Janica L, Franitza Marek, Georgomonolis Theodoros, Reinart Nina, Herling Marco, Herling Carmen, Hartmann Elena M, Rosenwald Andreas, Klapper Wolfram, Büttner Reinhard, Moia Riccardo, Rossi Davide, Boldorini Renzo, Gaidano Gianluca, Frenzel Lukas P, Reinhardt Hans Christian, Brüning Jens C, Hallek Michael, Krüger Marcus, Peifer Martin, Pallasch Christian P, Wunderlich F Thomas

Abstract excerpt

Richter's transformation (RT) is an aggressive lymphoma that occurs upon progression from chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic aberrations in the CLL phase involving TP53, CDKN2A, MYC, and NOTCH1; however, a significant proportion of RT cases lack CLL phase-associated events. Here, we report that high levels of AKT phosphorylation occur both in high-risk CLL patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Lymphoma, Large B-Cell, Diffuse

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Notch1

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Identifiers

PMID: 33538798
DOI: 10.1182/blood.2020005734

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