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Article

A phylogenetic method for detecting positive epistasis in gene sequences and its application to RNA virus evolution.

Molecular biology and evolution - 1 Sept 2006

Shapiro Beth, Rambaut Andrew, Pybus Oliver G, Holmes Edward C

Abstract excerpt

RNA virus genomes are compact, often containing multiple overlapping reading frames and functional secondary structure. Consequently, it is thought that evolutionary interactions between nucleotide sites are commonplace in the genomes of these infectious agents. However, the role of epistasis in...

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PMID: 16774976
DOI: 10.1093/molbev/msl037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16774976-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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