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Article

Integration of transcriptome-wide association study with neuronal dysfunction assays provides functional genomics evidence for Parkinson's disease genes.

Human molecular genetics - 27 Jan 2023

Li Jiayang, Amoh Bismark Kojo, McCormick Emma, Tarkunde Akash, Zhu Katy Fan, Perez Alma, Mair Megan, Moore Justin, Shulman Joshua M, Al-Ramahi Ismael, Botas Juan

Abstract excerpt

Genome-wide association studies (GWAS) have markedly advanced our understanding of the genetics of Parkinson's disease (PD), but they currently do not account for the full heritability of PD. In many cases it is difficult to unambiguously identify a specific gene within each locus because GWAS does not provide functional information on the identified candidate loci. Here we present an integrative approach that...

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Identifiers

PMID: 36173927
DOI: 10.1093/hmg/ddac230
PMCID: PMC9896475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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