Article
Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice.
Nature communications - 28 Sept 2022
O'Shea T M, Ao Y, Wang S, Wollenberg A L, Kim J H, Ramos Espinoza R A, Czechanski A, Reinholdt L G, Deming T J, Sofroniew M V
Abstract excerpt
Neural progenitor cells (NPC) represent potential cell transplantation therapies for CNS injuries. To understand how lesion environments influence transplanted NPC fate in vivo, we derived NPC expressing a ribosomal protein-hemagglutinin tag (RiboTag) for transcriptional profiling of transplanted NPC. Here, we show that NPC grafted into uninjured mouse CNS generate cells that are transcriptionally similar to...
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