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Article

Injury to the Spinal Cord Niche Alters the Engraftment Dynamics of Human Neural Stem Cells

18 Apr 2014

Abstract excerpt

The microenvironment is a critical mediator of stem cell survival, proliferation, migration, and differentiation. The majority of preclinical studies involving transplantation of neural stem cells (NSCs) into the CNS have focused on injured or degenerating microenvironments, leaving a dearth of information as to how NSCs differentially respond to intact versus damaged CNS. Furthermore, single, terminal...

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PMID: 24936450
DOI: 10.1016/j.stemcr.2014.03.005

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