Article
Injury primes mutation-bearing astrocytes for dedifferentiation in later life.
Current biology : CB - 27 Mar 2023
Simpson Ragdale Holly, Clements Melanie, Tang Wenhao, Deltcheva Elitza, Andreassi Catia, Lai Alvina G, Chang Wai Hoong, Pandrea Maria, Andrew Ivan, Game Laurence, Uddin Imran, Ellis Michael, Enver Tariq, Riccio Antonella, Marguerat Samuel, Parrinello Simona
Abstract excerpt
Despite their latent neurogenic potential, most normal parenchymal astrocytes fail to dedifferentiate to neural stem cells in response to injury. In contrast, aberrant lineage plasticity is a hallmark of gliomas, and this suggests that tumor suppressors may constrain astrocyte dedifferentiation. Here, we show that p53, one of the most commonly inactivated tumor suppressors in glioma, is a gatekeeper of astrocyte...
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