Article
Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury.
Molecular brain - 8 Jan 2013
Nishimura Soraya, Yasuda Akimasa, Iwai Hiroki, Takano Morito, Kobayashi Yoshiomi, Nori Satoshi, Tsuji Osahiko, Fujiyoshi Kanehiro, Ebise Hayao, Toyama Yoshiaki, Okano Hideyuki, Nakamura Masaya
Abstract excerpt
BACKGROUND: The transplantation of neural stem/progenitor cells (NS/PCs) at the sub-acute phase of spinal cord injury, but not at the chronic phase, can promote functional recovery. However, the reasons for this difference and whether it involves the survival and/or fate of grafted cells under these two conditions remain unclear. To address this question, NS/PC transplantation was performed after contusive spinal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.