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Article

Mutations of tyrosine 467 in the human norepinephrine transporter attenuate HIV-1 Tat-induced inhibition of dopamine transport while retaining physiological function.

PloS one - 1 Jan 2022

Strauss Matthew J, Porter Katherine D, Quizon Pamela M, Davis Sarah E, Lin Steven, Yuan Yaxia, Martinez-Muniz Gustavo A, Sun Wei-Lun, Zhan Chang-Guo, Zhu Jun

Abstract excerpt

Dysregulation of dopaminergic transmission induced by the HIV-1 transactivator of transcription (Tat) has been implicated as a central factor in the development of HIV-1 associated neurocognitive disorders (HAND). We have demonstrated that the tyrosine470 residue of the human dopamine transporter (hDAT) plays a critical role in Tat-hDAT interaction. Based on the computational modeling predictions, the present...

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PMID: 36170295
DOI: 10.1371/journal.pone.0275182
PMCID: PMC9518868

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