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Article

Molecular mechanism of HIV-1 Tat interacting with human dopamine transporter.

ACS chemical neuroscience - 15 Apr 2015

Yuan Yaxia, Huang Xiaoqin, Midde Narasimha M, Quizon Pamela M, Sun Wei-Lun, Zhu Jun, Zhan Chang-Guo

Abstract excerpt

Nearly 70% of HIV-1-infected individuals suffer from HIV-associated neurocognitive disorders (HAND). HIV-1 transactivator of transcription (Tat) protein is known to synergize with abused drugs and exacerbate the progression of central nervous system (CNS) pathology. Cumulative evidence suggest that the HIV-1 Tat protein exerts the neurotoxicity through interaction with human dopamine transporter (hDAT) in the...

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Identifiers

PMID: 25695767
DOI: 10.1021/acschemneuro.5b00001
PMCID: PMC4400243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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