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Article

Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains.

Molecular pharmacology - 1 Dec 2000

Lin Z, Wang W, Uhl G R

Abstract excerpt

Cocaine blocks the normal role of the dopamine transporter (DAT) in terminating dopamine signaling and in restricting its spatial spread through molecular interactions that remain largely obscure. Cocaine analog structure-activity studies suggest roles for cationic and hydrophobic interactions between DAT, dopamine, cocaine, and the sodium and chloride ions whose gradients power uptake processes. Tryptophan...

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PMID: 11093799
DOI: 10.1124/mol.58.6.1581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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