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Article

Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter.

Scientific reports - 16 Jun 2017

Sun Wei-Lun, Quizon Pamela M, Yuan Yaxia, Zhang Wei, Ananthan Subramaniam, Zhan Chang-Guo, Zhu Jun

Abstract excerpt

Dopamine transporter (DAT) is the target of cocaine and HIV-1 transactivator of transcription (Tat) protein. Identifying allosteric modulatory molecules with potential attenuation of cocaine and Tat binding to DAT are of great scientific and clinical interest. We demonstrated that tyrosine 470 and 88 act as functional recognition residues in human DAT (hDAT) for Tat-induced inhibition of DA transport and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28623359
DOI: 10.1038/s41598-017-03771-0
PMCID: PMC5473888

Genes

SRI

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