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Article

Mutation of tyrosine 470 of human dopamine transporter is critical for HIV-1 Tat-induced inhibition of dopamine transport and transporter conformational transitions.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology - 1 Sept 2013

Midde Narasimha M, Huang Xiaoqin, Gomez Adrian M, Booze Rosemarie M, Zhan Chang-Guo, Zhu Jun

Abstract excerpt

HIV-1 Tat protein plays a crucial role in perturbations of the dopamine (DA) system. Our previous studies have demonstrated that Tat decreases DA uptake, and allosterically modulates DA transporter (DAT) function. In the present study, we have found that Tat interacts directly with DAT, leading to inhibition of DAT function. Through computational modeling and simulations, a potential recognition binding site of...

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Identifiers

PMID: 23645138
DOI: 10.1007/s11481-013-9464-6
PMCID: PMC3740080

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