Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal evolution in chronic lymphocytic leukemia is associated with an unmutated IGHV status and frequently leads to a combination of loss of TP53 and TP53 mutation.

Molecular biology reports - 1 Dec 2022

Bracher Susanne, Fuhrmann Irene, Jeromin Sabine, Nadarajah Niroshan, Kern Wolfgang, Haferlach Torsten, Haferlach Claudia, Stengel Anna

Abstract excerpt

BACKGROUND: Chromosomal abnormalities and gene mutations determine the prognosis of patients with chronic lymphocytic leukemia (CLL). Genetic lesions can be acquired by clonal evolution (CE) likely correlating with clinical progression. METHODS AND RESULTS: Samples of 169 CLL patients were analyzed for cytogenetic clonal evolution (CCE) and CE affecting the genes TP53 and SF3B1. Moreover, the mutational status of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Mutation

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 36169893
DOI: 10.1007/s11033-022-07888-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal evolution in chronic lymphocytic leukemia is associated with an unmutated IGHV status and frequently leads to a combination of loss of TP53 and TP53 mutation.PMID 36169893Read ↗

Clonal evolution in chronic lymphocytic leukemia: analysis of correlations with IGHV mutational status, NOTCH1 mutations and clinical significance.Semantic proximity Read ↗

Clonal evolution in chronic lymphocytic leukemia: impact of subclonality on disease progression.Semantic proximity Read ↗

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival.Semantic proximity Read ↗

TP53 mutations are early events in chronic lymphocytic leukemia disease progression and precede evolution to complex karyotypes.Semantic proximity Read ↗

High-risk clonal evolution in chronic B-lymphocytic leukemia: single-center interphase fluorescence in situ hybridization study and review of the literature.Semantic proximity Read ↗

The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia.Semantic proximity Read ↗

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemiaSemantic proximity Read ↗

Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia.Semantic proximity Read ↗

Therapy-driven clonal dynamics in chronic lymphocytic leukemia.Semantic proximity Read ↗

Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia: A Contemporary PerspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.