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Article

Clonal evolution in chronic lymphocytic leukemia: acquisition of high-risk genomic aberrations associated with unmutated VH, resistance to therapy, and short survival.

Haematologica - 1 Sept 2007

Stilgenbauer Stephan, Sander Sandrine, Bullinger Lars, Benner Axel, Leupolt Elke, Winkler Dirk, Kröber Alexander, Kienle Dirk, Lichter Peter, Döhner Hartmut

Abstract excerpt

In chronic lymphocytic leukemia (CLL), the acquisition of new genomic aberrations during the disease course (clonal evolution) is thought to be an infrequent phenomenon but comprehensive analyses are limited. Genomic aberrations were analyzed by fluorescence in situ hybridization (FISH) at various time points during the disease course of 64 CLL patients. Results were correlated with the mutation status of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunoglobulin Heavy Chains

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 17666364
DOI: 10.3324/haematol.10720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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