Article
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.
Cell - 14 Feb 2013
Landau Dan A, Carter Scott L, Stojanov Petar, McKenna Aaron, Stevenson Kristen, Lawrence Michael S, Sougnez Carrie, Stewart Chip, Sivachenko Andrey, Wang Lili, Wan Youzhong, Zhang Wandi, Shukla Sachet A, Vartanov Alexander, Fernandes Stacey M, Saksena Gordon, Cibulskis Kristian, Tesar Bethany, Gabriel Stacey, Hacohen Nir, Meyerson Matthew, Lander Eric S, Neuberg Donna, Brown Jennifer R, Getz Gad, Wu Catherine J
Abstract excerpt
Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the fraction of cancer cells harboring each somatic mutation. We identified driver mutations as predominantly clonal (e.g., MYD88, trisomy 12, and del(13q)) or subclonal (e.g., SF3B1 and TP53),...
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