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Article

Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2013

Ouillette Peter, Saiya-Cork Kamlai, Seymour Erlene, Li Cheng, Shedden Kerby, Malek Sami N

Abstract excerpt

PURPOSE: The identification of gene mutations and structural genomic aberrations that are critically involved in chronic lymphocytic leukemia (CLL) pathogenesis is still evolving. One may postulate that genomic driver lesions with effects on CLL cell proliferation, apoptosis thresholds, or chemotherapy resistance should increase in frequency over time when measured sequentially in a large CLL cohort. EXPERIMENTAL...

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Identifiers

PMID: 23620403
DOI: 10.1158/1078-0432.CCR-13-0138
PMCID: PMC3674194

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NOTCH1

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