Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.

doi:10.1182/blood-2015-07-659144

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Article

Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.

Blood - 28 Apr 2016

Nadeu Ferran, Delgado Julio, Royo Cristina, Baumann Tycho, Stankovic Tatjana, Pinyol Magda, Jares Pedro, Navarro Alba, Martín-García David, Beà Sílvia, Salaverria Itziar, Oldreive Ceri, Aymerich Marta, Suárez-Cisneros Helena, Rozman Maria, Villamor Neus, Colomer Dolors, López-Guillermo Armando, González Marcos, Alcoceba Miguel, Terol Maria José, Colado Enrique, Puente Xose S, López-Otín Carlos, Enjuanes Anna, Campo Elías

Abstract excerpt

Genomic studies have revealed the complex clonal heterogeneity of chronic lymphocytic leukemia (CLL). The acquisition and selection of genomic aberrations may be critical to understanding the progression of this disease. In this study, we have extensively characterized the mutational status of TP53, SF3B1, BIRC3, NOTCH1, and ATM in 406 untreated CLL cases by ultra-deep next-generation sequencing, which detected...

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PMID: 26837699
DOI: 10.1182/blood-2015-07-659144
PMCID: PMC4912011

Genes

NOTCH1
ATM

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