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Article

Clonal evolution in chronic lymphocytic leukemia: analysis of correlations with IGHV mutational status, NOTCH1 mutations and clinical significance.

Genes, chromosomes & cancer - 1 Oct 2013

López Cristina, Delgado Julio, Costa Dolors, Villamor Neus, Navarro Alba, Cazorla Maite, Gómez Cándida, Arias Amparo, Muñoz Concha, Cabezas Sandra, Baumann Tycho, Rozman María, Aymerich Marta, Colomer Dolors, Pereira Arturo, Cobo Francesc, López-Guillermo Armando, Campo Elías, Carrió Ana

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized with highly variable clinical course. The most common chromosomal abnormalities in CLL, using conventional and molecular cytogenetics, are trisomy 12, del(13)(q14), del(11)(q22-23), del(17)(p13), and del(6)(q21). Whereas the prognostic marker such as IGHV mutational status remains stable during course of the diseases, chromosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Multivariate Analysis

Share to Receptor, Notch1

Source

Identifiers

PMID: 23893575
DOI: 10.1002/gcc.22087

Genes

NOTCH1
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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