Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human RET Gene: An In Silico Study.

Human mutation - 1 Jan 2026

Anzoom Nabilah, Hossain Md Arju, Hossain Md Tanvir, Uddin Md Moin, Khan Mahfuj, Islam Md Shofiqul, Ansari Siddique Akber, Rahman Md Habibur

Abstract excerpt

The RET proto-oncogene plays a critical role in multiple cancers and developmental disorders, where nonsynonymous single nucleotide polymorphisms (nsSNPs) may alter protein stability, function, and therapeutic response. In this study, a total of 28,335 SNPs from the NCBI dbSNP database, including 2377 nsSNPs, were systematically analyzed using 10 in silico prediction tools. Among these 33 high-risk variants were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indazoles

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Mas

Share to Proto-Oncogene Proteins c-ret

Source

Open in PubMed Open full text

Identifiers

PMID: 42369210
DOI: 10.1155/humu/8848146
PMCID: PMC13309746

Genes

RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling the Effects of Single Nucleotide Polymorphisms (SNPs) on the Structure and Function of the Human RET Gene: An In Silico Study.PMID 42369210Read ↗

In silico profiling and structural insights of missense mutations in RET protein kinase domain by molecular dynamics and docking approach.Semantic proximity Read ↗

Characterization of wild-type and mutated RET proto- oncogene associated with familial medullary thyroid cancer.Semantic proximity Read ↗

Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.Semantic proximity Read ↗

Prediction of Deleterious Non-synonymous SNPs of Human STK11 Gene by Combining Algorithms, Molecular Docking, and Molecular Dynamics Simulation.Semantic proximity Read ↗

Structure-based mechanistic principles underlying the paradoxical effects of pathological RET mutationsSemantic proximity Read ↗

Systematic Analysis of Tyrosine Kinase Inhibitor Response to RET Gatekeeper Mutations in Thyroid Cancer.Semantic proximity Read ↗

Systematic structure-based analysis of RET variants in MEN2A and Hirschsprung's disease, and the paradoxical co-occurrence of both conditions.Semantic proximity Read ↗

Predicting the impact of deleterious mutations in the protein kinase domain of FGFR2 in the context of function, structure, and pathogenesis--a bioinformatics approach.Semantic proximity Read ↗

Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer.Semantic proximity Read ↗

Precision oncology for RET-related tumorsSemantic proximity Read ↗

Targeting RET alterations in cancer: Recent progress and future directions.Semantic proximity Read ↗

An In silico Approach towards Finding the Cancer-Causing Mutations in Human MET GeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.