Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of Mutational Signatures in Tumors from a Large Chinese Population.

Cancer research communications - 1 Aug 2025

Chevalier Aaron, Guo Tao, Gurevich Natasha Q, Xu Jingwen, Yajima Masanao, Campbell Joshua D

Abstract excerpt

The majority of mutational signatures have been characterized in tumors from American and European countries, and the degree to which mutational signatures are similar to or different from those in Chinese populations has not been fully explored. We leveraged a large-scale clinical sequencing cohort of tumors from the Chinese population developed by OrigiMed (OM). A total of 2,115 tumors from 25 major tumor types...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to China
Share to Cohort Studies
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to East Asian People

Share to POLE gene

Share to Mutation

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 40778578
DOI: 10.1158/2767-9764.CRC-24-0496
PMCID: PMC12395221

Genes

POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of Mutational Signatures in Tumors from a Large Chinese Population.PMID 40778578Read ↗

Characterization of highly active mutational signatures in tumors from a large Chinese populationSemantic proximity Read ↗

Landscape of somatic alterations in large-scale solid tumors from an Asian populationSemantic proximity Read ↗

Clinical and genomic characterization of mutational signatures across human cancers.Semantic proximity Read ↗

Landscape of somatic alterations in large-scale solid tumors from an Asian population.Semantic proximity Read ↗

Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients.Semantic proximity Read ↗

Comprehensive genomic profiling of Chinese lung cancer characterizes germline-somatic mutation interactions influencing cancer riskSemantic proximity Read ↗

Mutational burden and signatures in 4000 Japanese cancers provide insights into tumorigenesis and response to therapySemantic proximity Read ↗

Somatic Mutaome Profile in Human Cancer TissuesSemantic proximity Read ↗

Mutational signatures: experimental design and analytical frameworkSemantic proximity Read ↗

Signatures of mutational processes in human cancer.Semantic proximity Read ↗

A fresh look at somatic mutations in cancer.Semantic proximity Read ↗

Mutation burden-orthogonal tumor genomic subtypes delineate responses to immune checkpoint therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.