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Article

miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer

7 Aug 2019

Abstract excerpt

Background Indoleamine 2,3-dioxygenase 1 (IDO1) is a critical regulator of T cell function, contributing to immune tolerance. Upregulation of IDO1 has been found in many cancer types; however, the regulatory mechanisms and clinical significance of IDO1 in colon cancer are still unclear. Here, we investigated the role of dysregulated microRNA (miRNA) targeting IDO1 in the colon cancer microenvironment. Methods We...

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PMID: 31391111
DOI: 10.1186/s40425-019-0691-0

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